Kratom, a Southeast Asian herb, is gaining attention as both a supplement for pain and fatigue and as a substance with possible risks for abuse and toxicity. The leaves of Mitragyna speciosa contain alkaloids like mitragynine, which interact with opioid receptors, producing effects similar to opioid drugs—though typically milder. While users report stimulant and mood-enhancing benefits, scientific reviews note concerning side effects, including possible liver toxicity, withdrawal, and psychological symptoms such as aggression and psychosis.
The U.S. FDA and DEA are debating whether kratom should face tighter regulation, given reports of overdose and dozens of deaths where kratom compounds were present, though causality is unclear. Experts urge rigorous clinical trials and scientific scrutiny rather than treating kratom as just another herbal supplement. For a full review and references, see the original article at Science-Based Medicine.
